Metformin Sandoz is prescribed for the management of Type 2 diabetes mellitus when diet modification and physical activity alone fail to maintain adequate glycemic control—particularly in individuals with excess body weight.

It may be utilized as:

Monotherapy, or in combination with other oral hypoglycemic agents, or alongside insulin for adult patients.
Monotherapy or adjunct therapy with insulin in children aged 10 years and older, as well as adolescents.

In adults with Type 2 diabetes and excessive body weight, Metformin Sandoz serves as a first-line treatment following unsuccessful dietary intervention, helping to reduce long-term diabetic complications.

Composition & Storage

Active substance: Metformin hydrochloride.

Each tablet contains 500 mg of metformin hydrochloride.

Excipients: Povidone, magnesium stearate.
Film coating: Hypromellose, titanium dioxide (E171), macrogol 4000.

Store the tablets in their original packaging, away from moisture and heat, and always out of reach of children. No special storage conditions are required.

Contraindications

Metformin Sandoz should not be used in the following cases:

Hypersensitivity to metformin or any other component of the formulation.
Any acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis).
Diabetic precoma.
Severe renal impairment (glomerular filtration rate < 30 mL/min).
Acute conditions predisposing to renal dysfunction, including:

Severe dehydration, serious infections, or shock.

Method of Administration

Metformin Sandoz may be used alone or in combination with other oral hypoglycemic agents.

Adults:

Initial dose: 500 mg or 850 mg, taken 2–3 times daily, during or immediately after meals.
After 10–15 days, dosage adjustments should be based on blood glucose measurements.
Gradual titration minimizes gastrointestinal side effects.
Maximum recommended daily dose: 3000 mg, divided into three doses.

When switching from another antidiabetic medication, discontinue the previous agent before starting Metformin.

Combination with insulin:
Metformin (500 mg or 850 mg, 2–3 times daily) may be administered alongside insulin for improved glycemic control. Insulin dosage should be adjusted according to blood glucose readings.

Elderly patients:
As renal function may decline with age, the dose must be determined following regular renal assessment.

Special Considerations

Pregnancy and Breastfeeding:

Uncontrolled diabetes during pregnancy increases the risk of congenital anomalies and perinatal mortality.
Although limited studies show no elevated risk of malformations, insulin remains the preferred treatment during pregnancy.

Metformin passes into breast milk, though adverse effects in breastfed infants have not been observed.
However, due to limited safety data, breastfeeding is not recommended during therapy. The decision to discontinue breastfeeding should weigh maternal benefit against potential infant risk.

Use in Children

Metformin Sandoz is approved for children over 10 years of age.

Effect on Driving and Machinery

Metformin monotherapy does not cause hypoglycemia and therefore does not impair alertness or reaction time.
Caution is advised when combined with other hypoglycemic agents (such as insulin or sulfonylureas) due to possible hypoglycemia risk.

Overdose

An intake of up to 85 g of metformin has not been associated with hypoglycemia but has led to lactic acidosis.
Significant overdose or predisposing risk factors can precipitate this condition.

If lactic acidosis is suspected:

Discontinue treatment immediately.
Hospitalization is required.
Hemodialysis is the most effective method to eliminate both lactate and metformin from the bloodstream.

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Storage Conditions

Store below 25°C, in a dry place, away from direct sunlight.
Keep out of the reach of children.
No special storage precautions are necessary.

Metformin Sandoz remains a cornerstone in Type 2 diabetes management—an effective, time-tested therapy for restoring metabolic balance and preventing long-term complications.

FAQs

1. What is Metformin Sandoz used for?

Metformin Sandoz is used to help control blood sugar levels in people with Type 2 diabetes mellitus, especially when diet and exercise alone are not enough. It can be taken alone, with other diabetes tablets, or together with insulin

2. How does Metformin Sandoz work?

It improves your body’s sensitivity to insulin and helps your cells use glucose more efficiently. This reduces high blood sugar levels without causing sudden drops in glucose when used alone.

3. Can Metformin Sandoz be used in children?

Yes, Metformin Sandoz can be prescribed for children aged 10 years and older and for adolescents, either alone or with insulin, under medical supervision.

4. Is Metformin Sandoz safe during pregnancy or breastfeeding?

During pregnancy, insulin is usually preferred to control blood glucose levels.
Although metformin passes into breast milk, there is limited safety data. Therefore, breastfeeding while on Metformin Sandoz is not recommended unless advised by your doctor.

5. What are the common side effects of Metformin Sandoz?

The most common side effects include nausea, diarrhea, abdominal discomfort, and loss of appetite, especially when treatment begins. These usually improve with time or when the dose is increased gradually and taken with food.

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